Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
If you’re looking for a comforting and hearty meal that combines two favorites, you’re in for a treat! This Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup is just what you need. Imagine layers of creamy macaroni and cheese nestled atop savory meatloaf. It’s a dish that warms the heart and fills the belly, making it perfect for family dinners or cozy nights at home.
I love this recipe because it brings together the best of both worlds. Whether it’s a busy weeknight or a family gathering, this casserole is sure to impress. Plus, it’s simple enough to whip up after a long day while still feeling like a special occasion. Let’s dive into why you’ll love this delightful dish!
Why You’ll Love This Recipe
- Easy to prepare: With straightforward steps and minimal fuss, this casserole comes together quickly.
- Family-friendly: Kids and adults alike will devour this comforting dish, making it perfect for family meals.
- Make-ahead convenience: Prepare it in advance and pop it in the oven when you’re ready to eat!
- Deliciously satisfying: The combination of flavors creates a rich and hearty meal that everyone will enjoy.

Ingredients You’ll Need
Let’s gather some simple, wholesome ingredients for this delicious casserole. You probably have most of them in your pantry already!
For the Meatloaf
- Ground Beef: 1 lb
- Onion: 1/2 cup, diced
- Breadcrumbs: 1/2 cup
- Egg: 1 large
- Milk: 1/4 cup
- Salt: 1 tsp
- Pepper: 1/2 tsp
For the Mac and Cheese
- Macaroni: 2 cups, uncooked
- Cheddar Cheese: 2 cups, shredded
- Butter: 2 tbsp
- Flour: 2 tbsp
- Milk: 2 cups
- Salt: 1/2 tsp
- Pepper: 1/4 tsp
- Paprika: 1/2 tsp
- Dry Mustard: 1/2 tsp
Variations
One of the best things about this Mac and Cheese Meatloaf Casserole is its flexibility! Feel free to customize it to suit your taste or whatever ingredients you have on hand.
- Swap the protein: Use ground turkey or chicken instead of beef for a lighter option.
- Add veggies: Stir in cooked broccoli or spinach into the mac and cheese for extra nutrition.
- Change up the cheese: Try using different types of cheese like gouda or mozzarella for varied flavors.
- Make it spicy: Add some diced jalapeños or a dash of hot sauce to give your casserole a kick!
How to Make Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Step 1: Preheat Oven
Preheat your oven to 350°F (175°C). This ensures that our casserole bakes evenly and gets that lovely golden top we’re dreaming about.
Step 2: Prepare Meatloaf
In a bowl, combine your ground beef, diced onion, breadcrumbs, egg, milk, salt, and pepper. Mix well until combined. Press this mixture firmly into the bottom of a greased 9×13-inch baking dish. This forms the hearty base of our casserole!
Step 3: Bake Meatloaf
Pop your meatloaf into the preheated oven and bake for about 20 minutes. This initial baking helps set the meatloaf so it holds up under all that cheesy goodness.
Step 4: Cook Macaroni
While your meatloaf is baking away, cook the macaroni according to package directions. Drain it once done and set aside. We want perfectly cooked pasta to soak up that creamy cheese sauce.
Step 5: Make Cheese Sauce
In a saucepan over medium heat, melt butter. Once melted, stir in flour and cook for one minute—this creates our roux. Gradually whisk in milk until thickened; then stir in salt, pepper, paprika, dry mustard, and finally add in about 1½ cups of shredded cheese until everything is melted together beautifully.
Step 6: Combine
Now it’s time for the magic! Stir your cooked macaroni into that luscious cheese sauce until well coated. Pour this cheesy goodness over your partially cooked meatloaf and sprinkle any remaining cheese on top—because who doesn’t love extra cheese?
Step 7: Bake Again
Return your casserole to the oven for an additional 25 minutes or until the cheese is melted and bubbly. Your kitchen will smell amazing as it bakes!
And there you have it—a delightful dish that’s easy enough for any night but special enough for gatherings! Enjoy every cheesy bite!
Pro Tips for Making Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
This delicious dish is sure to impress, and a few handy tips will help you achieve the perfect comfort food experience!
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Use lean ground beef: Opting for lean ground beef helps reduce excess fat in your casserole, making it a bit healthier while still keeping that rich flavor.
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Don’t overcook the macaroni: Cooking the macaroni just until al dente ensures it won’t become mushy after baking, allowing it to hold its shape and texture within the casserole.
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Experiment with cheese: While cheddar is classic, mixing in other cheeses like mozzarella or gouda can add depth and complexity to your cheese sauce, making every bite a delightful surprise.
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Let it rest before serving: Allowing the casserole to sit for about 10 minutes after baking helps it set up nicely, making it easier to cut into squares without falling apart.
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Customize your seasoning: Feel free to add your favorite herbs or spices to the meatloaf mixture or cheese sauce—think garlic powder or Italian seasoning—for extra flavor tailored to your taste.
How to Serve Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Presenting this casserole can be just as comforting as enjoying it! Here are some creative ideas to elevate your serving game.
Garnishes
- Chopped fresh parsley: A sprinkle of vibrant green parsley adds a pop of color and a fresh flavor contrast that brightens up each serving.
- Crushed red pepper flakes: If you enjoy a little heat, adding crushed red pepper flakes on top can bring an exciting kick to every bite.
Side Dishes
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Steamed broccoli: This simple side adds a nutritious green element that complements the richness of the casserole while being quick and easy to prepare.
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Garlic bread: Crispy garlic bread provides a wonderful crunch and flavor that pairs perfectly with creamy dishes like this mac and cheese meatloaf casserole.
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Mixed green salad: A light salad with fresh vegetables and a tangy vinaigrette offers a refreshing balance to the hearty casserole, making for a well-rounded meal.
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Roasted vegetables: Seasonal roasted veggies bring warmth and sweetness that harmonizes beautifully with the savory flavors of the meatloaf and cheesy macaroni.
Enjoy creating this ultimate comfort food mashup—it’s sure to become a family favorite!

Make Ahead and Storage
This Mac and Cheese Meatloaf Casserole is perfect for meal prep! You can easily make it in advance, store it, and enjoy it later. Here’s how to keep your delicious creation fresh.
Storing Leftovers
- Allow the casserole to cool completely at room temperature.
- Transfer leftovers to an airtight container.
- Store in the refrigerator for up to 3 days.
Freezing
- Let the casserole cool down before freezing.
- Cut into individual portions and wrap them tightly in plastic wrap or aluminum foil.
- Place wrapped portions in a freezer-safe container or bag.
- Freeze for up to 3 months.
Reheating
- Thaw overnight in the refrigerator if frozen.
- Preheat the oven to 350°F (175°C).
- Place the casserole in an oven-safe dish and cover with foil.
- Bake for about 20-25 minutes or until heated through. For added cheesiness, uncover during the last few minutes.
FAQs
Here are some common questions about this recipe!
Can I make Mac and Cheese Meatloaf Casserole ahead of time?
Absolutely! This casserole is great for meal prep. You can assemble it ahead of time and store it in the refrigerator until you’re ready to bake.
What can I use instead of beef in Mac and Cheese Meatloaf Casserole?
You can substitute ground turkey or chicken for a leaner option. The flavors will still hold up beautifully!
How long does Mac and Cheese Meatloaf Casserole last in the fridge?
When stored properly, this casserole will last for about 3 days in the refrigerator. Just make sure it’s in an airtight container!
Can I freeze Mac and Cheese Meatloaf Casserole?
Yes! This casserole freezes well. Just be sure to wrap individual portions tightly before placing them in a freezer-safe container.
Final Thoughts
I hope you enjoy making this Mac and Cheese Meatloaf Casserole as much as I do! It’s a delightful blend of comfort foods that bring warmth and joy to any family gathering or cozy night in. Don’t hesitate to try this recipe; it’s sure to become a favorite at your dinner table. Happy cooking!
Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Indulge in the ultimate comfort food experience with our Mac and Cheese Meatloaf Casserole. This delectable dish combines two beloved classics into one hearty masterpiece, featuring layers of creamy macaroni and cheese resting atop a savory meatloaf base. Perfect for family dinners or cozy nights, this casserole is not just easy to prepare but also versatile enough to customize according to your taste. Whether you’re looking for a quick weeknight meal or a special dish for gatherings, this Mac and Cheese Meatloaf Casserole is sure to impress everyone at the table!
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: Serves approximately 6 people 1x
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
- 1 lb ground beef
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk
- 2 cups uncooked macaroni
- 2 cups shredded cheddar cheese
- 2 tbsp butter
- 2 tbsp flour
- 2 cups milk (for cheese sauce)
- Salt to taste
- Pepper to taste
Instructions
- Preheat oven to 350°F (175°C). Grease a 9×13-inch baking dish.
- In a bowl, mix ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, salt, and pepper until well combined. Press into the bottom of the baking dish.
- Bake meatloaf for about 20 minutes.
- Cook macaroni according to package instructions; drain and set aside.
- In a saucepan, melt butter over medium heat. Stir in flour and cook for one minute. Gradually whisk in 2 cups of milk until thickened; add seasonings and stir in 1½ cups cheese until melted.
- Combine cooked macaroni with cheese sauce and pour over meatloaf. Top with remaining cheese.
- Bake for an additional 25 minutes until bubbly.
Nutrition
- Serving Size: 1 slice (250g)
- Calories: 560
- Sugar: 6g
- Sodium: 800mg
- Fat: 30g
- Saturated Fat: 15g
- Unsaturated Fat: 12g
- Trans Fat: 0g
- Carbohydrates: 45g
- Fiber: 3g
- Protein: 30g
- Cholesterol: 120mg
